diff --git a/src/SignalR/clients/csharp/Http.Connections.Client/src/Internal/WebSocketsTransport.cs b/src/SignalR/clients/csharp/Http.Connections.Client/src/Internal/WebSocketsTransport.cs
index 02c3a9748e..257886462d 100644
--- a/src/SignalR/clients/csharp/Http.Connections.Client/src/Internal/WebSocketsTransport.cs
+++ b/src/SignalR/clients/csharp/Http.Connections.Client/src/Internal/WebSocketsTransport.cs
@@ -44,7 +44,7 @@ namespace Microsoft.AspNetCore.Http.Connections.Client.Internal
             {
                 // Full Framework will throw when trying to set the User-Agent header
                 // So avoid setting it in netstandard2.0 and only set it in netstandard2.1 and higher
-#if !NETSTANDARD2_0
+#if !NETSTANDARD2_0 && !NET461
                 _webSocket.Options.SetRequestHeader("User-Agent", Constants.UserAgentHeader.ToString());
 #else
                 // Set an alternative user agent header on Full framework