diff --git a/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeBuilder.cs b/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeBuilder.cs
index 00f742407d..d21a2c915f 100644
--- a/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeBuilder.cs
+++ b/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeBuilder.cs
@@ -57,17 +57,6 @@ namespace Microsoft.AspNetCore.Blazor.RenderTree
             entry = entry.WithElementSubtreeLength(_entries.Count - indexOfEntryBeingClosed);
         }
 
-        /// <summary>
-        /// Marks a previously appended component frame as closed. Calls to this method
-        /// must be balanced with calls to <see cref="OpenComponent{TComponent}"/>.
-        /// </summary>
-        public void CloseComponent()
-        {
-            var indexOfEntryBeingClosed = _openElementIndices.Pop();
-            ref var entry = ref _entries.Buffer[indexOfEntryBeingClosed];
-            entry = entry.WithComponentSubtreeLength(_entries.Count - indexOfEntryBeingClosed);
-        }
-
         /// <summary>
         /// Appends a frame representing text content.
         /// </summary>
@@ -171,6 +160,39 @@ namespace Microsoft.AspNetCore.Blazor.RenderTree
             Append(RenderTreeFrame.ChildComponent<TComponent>(sequence));
         }
 
+        /// <summary>
+        /// Marks a previously appended component frame as closed. Calls to this method
+        /// must be balanced with calls to <see cref="OpenComponent{TComponent}"/>.
+        /// </summary>
+        public void CloseComponent()
+        {
+            var indexOfEntryBeingClosed = _openElementIndices.Pop();
+            ref var entry = ref _entries.Buffer[indexOfEntryBeingClosed];
+            entry = entry.WithComponentSubtreeLength(_entries.Count - indexOfEntryBeingClosed);
+        }
+
+        /// <summary>
+        /// Appends a frame denoting the start of a region (that is, a tree fragment that is
+        /// processed as a unit for the purposes of diffing).
+        /// </summary>
+        /// <param name="sequence">An integer that represents the position of the instruction in the source code.</param>
+        public void OpenRegion(int sequence)
+        {
+            _openElementIndices.Push(_entries.Count);
+            Append(RenderTreeFrame.Region(sequence));
+        }
+
+        /// <summary>
+        /// Marks a previously appended region frame as closed. Calls to this method
+        /// must be balanced with calls to <see cref="OpenRegion"/>.
+        /// </summary>
+        internal void CloseRegion()
+        {
+            var indexOfEntryBeingClosed = _openElementIndices.Pop();
+            ref var entry = ref _entries.Buffer[indexOfEntryBeingClosed];
+            entry = entry.WithRegionSubtreeLength(_entries.Count - indexOfEntryBeingClosed);
+        }
+
         private void AssertCanAddAttribute()
         {
             if (_lastNonAttributeFrameType != RenderTreeFrameType.Element
diff --git a/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrame.cs b/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrame.cs
index 2f113b6b46..81b45ed5bc 100644
--- a/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrame.cs
+++ b/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrame.cs
@@ -118,6 +118,17 @@ namespace Microsoft.AspNetCore.Blazor.RenderTree
         /// </summary>
         [FieldOffset(24)] public readonly IComponent Component;
 
+        // --------------------------------------------------------------------------------
+        // RenderTreeFrameType.Region
+        // --------------------------------------------------------------------------------
+
+        /// <summary>
+        /// If the <see cref="FrameType"/> property equals <see cref="RenderTreeFrameType.Region"/>
+        /// gets the number of frames in the subtree for which this frame is the root.
+        /// The value is zero if the frame has not yet been closed.
+        /// </summary>
+        [FieldOffset(8)] public readonly int RegionSubtreeLength;
+
         private RenderTreeFrame(int sequence, string elementName, int elementSubtreeLength)
             : this()
         {
@@ -170,6 +181,14 @@ namespace Microsoft.AspNetCore.Blazor.RenderTree
             AttributeEventHandlerId = eventHandlerId;
         }
 
+        private RenderTreeFrame(int sequence, int regionSubtreeLength)
+            : this()
+        {
+            FrameType = RenderTreeFrameType.Region;
+            Sequence = sequence;
+            RegionSubtreeLength = regionSubtreeLength;
+        }
+
         internal static RenderTreeFrame Element(int sequence, string elementName)
             => new RenderTreeFrame(sequence, elementName: elementName, elementSubtreeLength: 0);
 
@@ -185,6 +204,9 @@ namespace Microsoft.AspNetCore.Blazor.RenderTree
         internal static RenderTreeFrame ChildComponent<T>(int sequence) where T : IComponent
             => new RenderTreeFrame(sequence, typeof(T), 0);
 
+        internal static RenderTreeFrame Region(int sequence)
+            => new RenderTreeFrame(sequence, regionSubtreeLength: 0);
+
         internal RenderTreeFrame WithElementSubtreeLength(int elementSubtreeLength)
             => new RenderTreeFrame(Sequence, elementName: ElementName, elementSubtreeLength: elementSubtreeLength);
 
@@ -199,5 +221,8 @@ namespace Microsoft.AspNetCore.Blazor.RenderTree
 
         internal RenderTreeFrame WithAttributeEventHandlerId(int eventHandlerId)
             => new RenderTreeFrame(Sequence, AttributeName, AttributeValue, eventHandlerId);
+
+        internal RenderTreeFrame WithRegionSubtreeLength(int regionSubtreeLength)
+            => new RenderTreeFrame(Sequence, regionSubtreeLength: regionSubtreeLength);
     }
 }
diff --git a/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrameType.cs b/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrameType.cs
index 9a899c84ec..ffc936958f 100644
--- a/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrameType.cs
+++ b/src/Microsoft.AspNetCore.Blazor/RenderTree/RenderTreeFrameType.cs
@@ -27,5 +27,13 @@ namespace Microsoft.AspNetCore.Blazor.RenderTree
         /// Represents a child component.
         /// </summary>
         Component = 4,
+
+        /// <summary>
+        /// Defines the boundary around range of sibling frames that should be treated as an
+        /// unsplittable group for the purposes of diffing. This is typically used when appending
+        /// a tree fragment generated by external code, because the sequence numbers in that tree
+        /// fragment are not comparable to sequence numbers outside it.
+        /// </summary>
+        Region = 5,
     }
 }
diff --git a/test/Microsoft.AspNetCore.Blazor.Test/RenderTreeBuilderTest.cs b/test/Microsoft.AspNetCore.Blazor.Test/RenderTreeBuilderTest.cs
index 84fdcc0c37..68c7bc5d6a 100644
--- a/test/Microsoft.AspNetCore.Blazor.Test/RenderTreeBuilderTest.cs
+++ b/test/Microsoft.AspNetCore.Blazor.Test/RenderTreeBuilderTest.cs
@@ -245,6 +245,20 @@ namespace Microsoft.AspNetCore.Blazor.Test
             });
         }
 
+        [Fact]
+        public void CannotAddAttributeToRegion()
+        {
+            // Arrange
+            var builder = new RenderTreeBuilder(new TestRenderer());
+
+            // Act/Assert
+            Assert.Throws<InvalidOperationException>(() =>
+            {
+                builder.OpenRegion(0);
+                builder.AddAttribute(1, "name", "value");
+            });
+        }
+
         [Fact]
         public void CanAddChildComponents()
         {
@@ -272,6 +286,34 @@ namespace Microsoft.AspNetCore.Blazor.Test
                 frame => AssertFrame.Attribute(frame, "child2attribute", "C"));
         }
 
+        [Fact]
+        public void CanAddRegions()
+        {
+            // Arrange
+            var builder = new RenderTreeBuilder(new TestRenderer());
+
+            // Act
+            builder.OpenElement(10, "parent");                      //  0: <parent>
+            builder.OpenRegion(11);                                 //  1:     [region
+            builder.AddText(3, "Hello");                            //  2:         Hello
+            builder.OpenRegion(4);                                  //  3:         [region
+            builder.OpenElement(3, "another");                      //  4:             <another>
+            builder.CloseElement();                                 //                 </another>
+            builder.CloseRegion();                                  //             ]
+            builder.AddText(6, "Goodbye");                          //  5:         Goodbye
+            builder.CloseRegion();                                  //         ]
+            builder.CloseElement();                                 //     </parent>
+
+            // Assert
+            Assert.Collection(builder.GetFrames(),
+                frame => AssertFrame.Element(frame, "parent", 6, 10),
+                frame => AssertFrame.Region(frame, 5, 11),
+                frame => AssertFrame.Text(frame, "Hello", 3),
+                frame => AssertFrame.Region(frame, 2, 4),
+                frame => AssertFrame.Element(frame, "another", 1, 3),
+                frame => AssertFrame.Text(frame, "Goodbye", 6));
+        }
+
         [Fact]
         public void CanClear()
         {
diff --git a/test/shared/AssertFrame.cs b/test/shared/AssertFrame.cs
index faa9b1d497..64d25559b4 100644
--- a/test/shared/AssertFrame.cs
+++ b/test/shared/AssertFrame.cs
@@ -67,6 +67,13 @@ namespace Microsoft.AspNetCore.Blazor.Test.Shared
             Assert.Equal(componentId, frame.ComponentId);
         }
 
+        public static void Region(RenderTreeFrame frame, int subtreeLength, int? sequence = null)
+        {
+            Assert.Equal(RenderTreeFrameType.Region, frame.FrameType);
+            Assert.Equal(subtreeLength, frame.RegionSubtreeLength);
+            AssertFrame.Sequence(frame, sequence);
+        }
+
         public static void Whitespace(RenderTreeFrame frame, int? sequence = null)
         {
             Assert.Equal(RenderTreeFrameType.Text, frame.FrameType);