In Angular2Spa, reference angular2-universal-patch. This will allow for upgrades to Angular 2.4.5.

templates/Angular2Spa/ClientApp/boot-server.ts

@@ -1,4 +1,5 @@
 import 'angular2-universal-polyfills';
+import 'angular2-universal-patch';
 import 'zone.js';
 import { createServerRenderer, RenderResult } from 'aspnet-prerendering';
 import { enableProdMode } from '@angular/core';

templates/Angular2Spa/package.json

@@ -18,6 +18,7 @@
     "angular2-platform-node": "~2.0.11",
     "angular2-template-loader": "^0.6.0",
     "angular2-universal": "~2.0.11",
+    "angular2-universal-patch": "^0.2.1",
     "angular2-universal-polyfills": "~2.0.11",
     "aspnet-prerendering": "^2.0.0",
     "aspnet-webpack": "^1.0.17",